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<\/figure>\r\n\r\n\r\n\r\nEl Alzheimer es la principal causa de demencia y la sexta de muerte en Estados Unidos. Sin embargo, a pesar de la creciente prevalencia y el aumento de los costes de esta afecci\u00f3n, a\u00fan no se conocen bien los factores gen\u00e9ticos y ambientales que hacen que algunos individuos sean m\u00e1s susceptibles a esta enfermedad.<\/p>\r\n\r\n\r\n\r\n
Al mejorar los exomas de 6.000 pacientes con Alzheimer con los de 5.000 adultos mayores cognitivamente sanos, los investigadores pudieron encontrar variaciones en genes que, seg\u00fan creen, pueden contribuir al desarrollo del Alzheimer.<\/p>\r\n\r\n\r\n\r\n
Los genes reci\u00e9n descubiertos pueden indicar una respuesta inflamatoria y cambios en la producci\u00f3n de prote\u00ednas. Se cree que ambos cambios contribuyen a la neurodegeneraci\u00f3n que se produce en el Alzheimer.<\/p>\r\n\r\n\r\n\r\n
\u201cEste amplio y profundo estudio de secuenciaci\u00f3n gen\u00e9tica es una parte importante para identificar qu\u00e9 variaciones pueden influir en el riesgo de contraer Alzheimer o en la protecci\u00f3n frente a esta enfermedad\u201d, afirma el Dr. Eliezer Masliah, Director de la Divisi\u00f3n de Neurociencia del Instituto Nacional sobre el Envejecimiento, que forma parte de los NIH.<\/p>\r\n\r\n\r\n\r\n
\u201cLos esfuerzos de big data como el ADSP est\u00e1n ayudando realmente a que la investigaci\u00f3n avance. La identificaci\u00f3n de variantes raras podr\u00eda mejorar nuestra capacidad para encontrar nuevas dianas terap\u00e9uticas y avanzar en los enfoques de medicina de precisi\u00f3n para la enfermedad de Alzheimer. \u201c<\/p>\r\n\r\n\r\n\r\n
El equipo subraya que ser\u00e1 necesario seguir investigando para encontrar otros genes ocultos en el genoma. Actualmente, los cient\u00edficos creen que la aparici\u00f3n del Alzheimer es el resultado de muchos genes y sus interacciones.<\/p>","protected":false},"excerpt":{"rendered":"
Researchers from Boston University School of Medicine, in collaboration with scientists from the Alzheimer’s Disease Sequencing Project (ADSP), have discovered new genes that could contribute to the onset of Alzheimer’s disease. The new discovery may advance precision medicine treatments for the degenerative condition. 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