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<\/figure>\r\n\r\n\r\n\r\nLa maladie d'Alzheimer est la principale cause de d\u00e9mence et la sixi\u00e8me cause de d\u00e9c\u00e8s aux \u00c9tats-Unis. Cependant, malgr\u00e9 la pr\u00e9valence croissante et les co\u00fbts de plus en plus \u00e9lev\u00e9s de cette maladie, les facteurs g\u00e9n\u00e9tiques et environnementaux qui rendent certains individus plus sensibles \u00e0 cette maladie ne sont pas encore bien compris.<\/p>\r\n\r\n\r\n\r\n
En comparant les exomes de 6 000 patients atteints de la maladie d'Alzheimer \u00e0 ceux de 5 000 personnes \u00e2g\u00e9es en bonne sant\u00e9 cognitive, les chercheurs ont pu trouver des variations dans les g\u00e8nes qui, selon eux, pourraient contribuer au d\u00e9veloppement de la maladie d'Alzheimer.<\/p>\r\n\r\n\r\n\r\n
Les g\u00e8nes nouvellement d\u00e9couverts peuvent indiquer une r\u00e9ponse inflammatoire et des changements dans la production de prot\u00e9ines. On pense que ces deux changements contribuent \u00e0 la neurod\u00e9g\u00e9n\u00e9rescence qui se produit dans la maladie d'Alzheimer.<\/p>\r\n\r\n\r\n\r\n
\u201cCette vaste \u00e9tude de s\u00e9quen\u00e7age g\u00e9n\u00e9tique est un \u00e9l\u00e9ment important pour identifier les variations qui peuvent jouer un r\u00f4le dans le risque de contracter la maladie d'Alzheimer ou dans la protection contre cette maladie\u201d, a d\u00e9clar\u00e9 le docteur Eliezer Masliah, directeur de la division des neurosciences au National Institute on Aging, qui fait partie du NIH.<\/p>\r\n\r\n\r\n\r\n
\u201cLes efforts en mati\u00e8re de big data, tels que l'ADSP, aident r\u00e9ellement la recherche \u00e0 progresser. L'identification de variantes rares pourrait am\u00e9liorer notre capacit\u00e9 \u00e0 trouver de nouvelles cibles th\u00e9rapeutiques et \u00e0 faire progresser les approches de m\u00e9decine de pr\u00e9cision pour la maladie d'Alzheimer. \u201c<\/p>\r\n\r\n\r\n\r\n
L'\u00e9quipe souligne que des recherches suppl\u00e9mentaires seront n\u00e9cessaires pour trouver d'autres g\u00e8nes cach\u00e9s dans le g\u00e9nome. Les scientifiques pensent actuellement que l'apparition de la maladie d'Alzheimer est le r\u00e9sultat de nombreux g\u00e8nes et de leurs interactions.<\/p>","protected":false},"excerpt":{"rendered":"
Researchers from Boston University School of Medicine, in collaboration with scientists from the Alzheimer’s Disease Sequencing Project (ADSP), have discovered new genes that could contribute to the onset of Alzheimer’s disease. The new discovery may advance precision medicine treatments for the degenerative condition. 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