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<\/figure>\r\n\r\n\r\n\r\nA doen\u00e7a de Alzheimer \u00e9 a principal causa de dem\u00eancia e a sexta principal causa de morte nos EUA. No entanto, apesar da preval\u00eancia crescente e dos custos cada vez maiores da doen\u00e7a, os fatores gen\u00e9ticos e ambientais que tornam alguns indiv\u00edduos mais suscet\u00edveis a essa doen\u00e7a ainda n\u00e3o s\u00e3o bem compreendidos.<\/p>\r\n\r\n\r\n\r\n
Ao aprimorar os exomas de 6.000 pacientes com Alzheimer com os de 5.000 idosos cognitivamente saud\u00e1veis, os pesquisadores conseguiram encontrar varia\u00e7\u00f5es nos genes que, segundo eles, podem contribuir para o desenvolvimento do Alzheimer.<\/p>\r\n\r\n\r\n\r\n
Os genes rec\u00e9m-descobertos podem indicar uma resposta inflamat\u00f3ria e altera\u00e7\u00f5es na produ\u00e7\u00e3o de prote\u00ednas. Acredita-se que essas duas altera\u00e7\u00f5es contribuam para a neurodegenera\u00e7\u00e3o que ocorre na doen\u00e7a de Alzheimer.<\/p>\r\n\r\n\r\n\r\n
\u201cEsse grande e profundo estudo de sequenciamento de genes \u00e9 uma parte importante da identifica\u00e7\u00e3o de quais varia\u00e7\u00f5es podem desempenhar um papel no risco de contrair Alzheimer ou na prote\u00e7\u00e3o contra a doen\u00e7a\u201d, disse Eliezer Masliah, MD, Diretor da Divis\u00e3o de Neuroci\u00eancia do Instituto Nacional do Envelhecimento, parte do NIH.<\/p>\r\n\r\n\r\n\r\n
\u201cOs esfor\u00e7os de Big Data, como o ADSP, est\u00e3o realmente ajudando a pesquisa a avan\u00e7ar. A identifica\u00e7\u00e3o de variantes raras pode aumentar nossa capacidade de encontrar novos alvos terap\u00eauticos e avan\u00e7ar nas abordagens de medicina de precis\u00e3o para a doen\u00e7a de Alzheimer. \u201c<\/p>\r\n\r\n\r\n\r\n
A equipe enfatiza que ser\u00e3o necess\u00e1rias mais pesquisas para encontrar outros genes ocultos no genoma. Atualmente, os cientistas acreditam que o in\u00edcio da doen\u00e7a de Alzheimer \u00e9 resultado de muitos genes e suas intera\u00e7\u00f5es.<\/p>","protected":false},"excerpt":{"rendered":"
Researchers from Boston University School of Medicine, in collaboration with scientists from the Alzheimer’s Disease Sequencing Project (ADSP), have discovered new genes that could contribute to the onset of Alzheimer’s disease. The new discovery may advance precision medicine treatments for the degenerative condition. The National Institutes of Health developed ADSP in response to the National 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