MegaSporeBiotic™ Probiotic — 60 & 180 Capsules

MegaSporeBiotic™ by Microbiome Labs is a spore-based probiotic with five Bacillus strains, formulated to support a healthy gut microbiome and gut barrier function.* Choose a 60-capsule or 180-capsule bottle using the size comparison above.

Each two-capsule serving supplies a 295 mg proprietary probiotic blend with 4 billion CFU. No refrigeration is required. For a broader introduction, read our MegaSporeBiotic complete guide.

Follow the directions on your bottle or your healthcare practitioner’s advice. The manufacturer’s gradual-start schedule is:

1. Week 1: 1 capsule every other day.
2. Week 2: 1 capsule per day.
3. Week 3 onward: 2 capsules per day, with food, or as recommended by your healthcare practitioner.

At 2 capsules per day, a 60-capsule bottle provides 30 days and a 180-capsule bottle provides 90 days. These are reference calculations, not a personalized dose recommendation. Starting gradually or following different practitioner directions changes how long a bottle lasts.

Research should be read in the context of the exact formula, participants and study design. A 2019 human study published in Nutrients evaluated MegaSporeBiotic in adults with irritable bowel syndrome over 60 days. It reported changes in study outcomes, including quality of life; it does not establish a guaranteed result for an individual shopper.

That study is distinct from research using several supplements together, animal experiments or laboratory gut models. Those findings should not be presented as equivalent evidence for this product alone. The NIH overview explains why probiotic effects depend on the strains and the condition studied.

If you are researching SIBO, our article discussing MegaSporeBiotic and SIBO provides further reading. It is educational information, not a diagnosis or a recommendation to treat SIBO with this supplement.